Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
- HLH-94 Protocol
• Dexamethasone
• Etoposide
• Cyclosporine (sometimes omitted)
• +/- intrathecal methotrexate (depending on CNS involvement)
- Followed by hematopoietic cell transplantation
Secondary HLH:
• Approach varies depending on trigger
• Almost all patients receive steroids
• In mild cases associated with infection or autoimmune disease, treatment of underlying condition may spare patient more toxic therapy
• Options for severe cases include: HLH-94, anakinra, IVIg, rituximab, alemtuzumab, tacrolimus
• Hematopoietic cell transplantation for refractory disease
- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi
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