Therapeutic Plasma Exchange - Circuit Diagram Goal = removal of abnormal/excess cells or substances that: • Have a long half life • Acutely toxic/resistant to conventional therapy • Large enough to be removed by pheresis Example: • Autoantibody • Immune complex • Cryoglobulin • Myeloma light chains • Endotoxin • Cholesterol-containing lipoprotein BWH Medicine Residency @BrighamMedRes #Plasma #Exchange #pathophysiology
