Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin, Scl70 (in some cases) Speckled pattern: • SjS, SLE, DM, SSc, PM/SSc OS, MCTD, UCTD • Smith, Sm/RNP, Scl-70, SSA-52 (Ro52), SSA-60 (Ro60), SSB (La), RNA polymerase III, Ku Centromere pattern: • SSc, PBC/SSc OS • CENP-A, CENP-B Nucleolar pattern: • SSc, PM/SSc OS, Raynaud phenomenon, SjS, cancer, other SARD • Fibrillarin, RNA polymerase III, PM/Scl100, Th/To, Scl-70 (in some cases) Nuclear dots pattern: • PBC, DM, other inflammatory conditions • Sp-100, PML, NXP-2 (MORC3 or MJ) ARUPConsult @ARUPLabs #ANA #Antinuclear #Antibody #Testing #Nuclear #Patterns #differential #diagnosis #rheumatology
