Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: • SLE, SjS, CTD-ILD, IIM, Raynaud phenomenon • EJ, Jo-1, OJ, PL-7, PL-12, MDA5, ribosomal P, SRP Discrete dots/GW body-like: • Neurologic conditions, SjS, SLE, RA, PBC, UCTD • Anti-GW182, anti-Su/Ago Golgi/polar: • SLE, SjS, RA, OSs, cerebellar ataxia • Giantin/macrogolgin, golgin-95/GM130, golgin-160, golgin97, golgin-245 Rods/rings: • HCV treated with pegylated interferon-α/ribaviron combination therapy • IMPDH2 ARUPConsult @ARUPLabs #ANA #Antinuclear #Antibody #Testing #Cytoplasmic #Patterns #differential #diagnosis #rheumatology
