Causes of Constipation - Differential Diagnosis Framework • Motility: Diet, IBS-C, Colonic inertia, Pelvic floor disorders, Hirschsprung's • Neurogenic: Stroke, Multiple sclerosis, Parkinson's disease, Spinal cord injury, Neuropathy / myopathy • Mechanical: Stricture, Tumour, Prolapse / rectocele, Diverticular disease, Extrinsic compression • Drugs: Opioids, TCAs / mood stabilizers, Diuretics, Iron, Calcium supplements, etc • Metabolic: Diabetes, ↑Ca2, ↓K, Hypothyroidism, Hyperparathyroidism, Chronic kidney failure • Others: Scleroderma, Coeliac disease, Anal pain (e.g. fissure), Chronic laxative use, Psychological Dr. Keith Siau @drkeithsiau #Constipation #Differential #Diagnosis #Causes
