Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis • Kidneys: CKD, ESRD • CV/Resp/Heme: CHF, valves, COPD, ILD, OSA, pHTN, Anemia • Psych: Depression, anxiety, Conversion "I am weak": • Myopathy: Drugs (statin, chemo), EtOH, Rhabdomyolysis, Critical illness, Infection • Neuro: UMN (stroke, tumor), LMN (Polyneuropathy, ALS), NMJ disorder (Myasthenia, LEMS, Drug/Toxin) • Inflammatory/Rheum: Myositis (dermato-, poly-, inclusion body-), PMR, RA, SLE, Vasculitis OVERLAP: • Thyroid ↑↓, Cortisol ↑↓, Malignancy, Infection Dr. Anand Jagannath @AnandJag1 #Generalized #Weakness #Differential #Diagnosis #causes #neurology
