Leptospirosis - Post-exposure Prophylaxis Why do we give prophylaxis against Leptospirosis? To prevent WEIL'S SYNDROME - Severe icteric form with ↑ mortality, 5-10% of all cases - Triad of 1) hemorrhage 2) jaundice 3) acute kidney injury - Classic hx: Wading in floods +conjunctival suffusion +calf tenderness - 50% of pts die of septic shock with multiorgan failure and/or bleeding in the lungs, GI, uro or skin HISTORY OF WADING IN FLOOD Low Risk: - Single exposure, no wounds/cuts/skin lesions - Doxycycline 2 capsules 100 mg single dose within 24 to 72 hours Moderate Risk: - Single exposure, +wounds/cuts/skin lesions - Doxycycline 2 capsules 100 mg OD for 3-5 days to be started immediately within 24 to 72 hours from exposure High Risk: - Continuous exposure, +/- wounds/cuts/skin lesions - Doxycycline 2 capsules 100 mg once weekly until the end of exposure #leptospirosis #Postexposure #prophylaxis #management
