Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a negative culture Brain: - Streptococcal spp - Fastidious: Nocardia, Brucella - Anaerobic: Prevotella, Bacteroides, Actinomyces, Fusobacteria - Acid-Fast: Mycobacteria - Fungal: Aspergillus, Cryptococcus, Mucormycosis, Fusarium, Scedosporium, endemic fungi - Parasitic: Toxoplasmosis, Entamoeba Skin: - Fastidious: Neisseria gonorrhoeae, bartonella, nocardia - Fungal: Cryptococcus, Sporothrix, Blastomycosis - Parasite: Dracunculiasis - Non-Infectious Auto-Inflammatory: PAPA, SAPHO, Sweet's Syndrome, hidradenitis suppurativa - Autoimmune: Crohn's disease, pyoderma gangrenosum - Lymphoma Bone: - Fastidious: Bartonella, Brucella, Coxiella, Neisseria gonorrhoeae, Burkholderia, Nocardia - No Cell Wall: Mycoplasma, Ureaplasma - Acid-Fast: Mycobacteria - Fungal: Aspergillus, Coccidiomycosis, Cryptococcus, Blastomycosis - Non-Infectious Auto-Inflammatory: SAPHO syndrome Kidneys: - No Cell Wall: Mycoplasma, Ureaplasma - Acid-Fast: Mycobacteria - Fungal: Aspergillus, histoplasmosis Liver / Spleen: - Streptococcal spp - Fastidious: Bartonella, Brucella, Coxiella, Burkholderia, cIostridium spp - Aerobic: Fusobacteria, Prevotella, Bacteroides - Acid-Fast: Mycobacteria - Fungal: Aspergillus, Mucormycosis, histoplasmosis, coccidiomycosis - Parasitic: Entamoeba Dr. Ann Marie Kumfer @AnnKumfer #Culture #Negative #Abscess #Differential #Diagnosis #InfectiousDiseases
