Propofol - Anesthesia Pharmacology Brand Name(s): Diprivan Drug Type: Induction and Maintenance Duration of Action: 3 - 8 minutes Mechanism of Action: Positive modulation of GABA-A receptor complex Cessation of Action: Hepatic and extrahepatic metabolism (lungs), redistribution to poorly perfused compartments Systems: - Central Nervous System: hypnotic with no analgesic properties; reduces CMR02 and the peripheral vasodilation results in decreased CBF - Cardiovascular: arterial and venous dilation reducing preload and afterload, blunts the baroreflex response, resulting in a lack of increased heart rate in response to a drop in blood pressure - Respiratory: reduces minute ventilation by markedly reducing tidal volume and somewhat decreasing respiratory rate; increases collapsibility of upper airway leading to apnea - Other: anti-emetic properties David Convissar, MD @countbackwardsfrom10 #Propofol #Anesthesia #Pharmacology #Diprivan
