Ketamine - Anesthesia Pharmacology Trade Name: Ketamine Brand Name(s): Ketalar Drug Type: Induction Time of Onset: Rapid Duration of Action: 5 - 10 minutes Mechanism of Action: Inhibition of the NMDA receptor complex Cessation of Action: Hepatic metabolism and redistribution to inactive tissue sites Systems: - Central Nervous System - Increases CBF and CMRO2 - Cardiovascular - large but transient increases in systemic arterial blood pressure, along with cardiac output and heart rate via inherent catecholamines. Otherwise, direct myocardia depressant. - Respiratory - relaxes bronchial smooth muscles but does not induce significant respiratory depression David Convissar, MD @countbackwardsfrom10 #Ketamine #Anesthesia #Pharmacology #Ketalar
