Dexmedetomidine - Anesthesia Pharmacology Trade Name: Dexmedetomidine Brand Name(s): Precedex Drug Type: Sedation Time of Onset: 30 minutes Duration of Action: N/A Mechanism of Action: Highly selective agonist of CNS alpha2-receptors Cessation of Action: Rapid hepatic metabolism Systems: - Central Nervous System - hypnotic agent due to stimulation of alpha2-receptors in the ceruleus, reducing its activity; sedative effect achieved by activation of endogenous sleep pathways; decreases CBF without significantly affecting CMRO2 and ICP - Cardiovascular - reduces heart rate and systemic vascular resistance, thus lowering systemic arterial blood pressure - Respiratory - moderately reduces tidal volume and to a lesser extent, respiratory rate David Convissar, MD @countbackwardsfrom10 #Dexmedetomidine #Precedex #Anesthesia #Pharmacology
