Esmolol - Anesthesia Pharmacology Trade Name: Esmolol Brand Name(s): Brevibloc Drug Type: Cardio-Selective ß Antagonist Time of Onset: Rapid Duration of Action: 10-20 minutes after discontinuing Cessation of Action: Metabolized by RBC esterases Cardiovascular Effects: - Cardio-selective ß antagonist, with low doses blocking ß-1 receptors causing a decrease in heart rate, contractility, and of atrioventricular conduction. - Loses selectivity at higher doses, causing ß-2 receptor antagonism, resulting in bronchoconstriction and peripheral vasoconstriction Uses: Supraventricular tachydysrhythmias, Myocardial ischemia, Intraoperative and postoperative hypertension and tachycardia David Convissar, MD @countbackwardsfrom10 #Esmolol #Brevibloc #Anesthesia #Pharmacology
