Epinephrine - Anesthesia Pharmacology Trade Name: Epinephrine Brand Name(s): Adrenalin Drug Type: Endogenous Catecholamine Time of Onset: Rapid Duration of Action: 1-2 minutes Mechanism of Action: Stimulates α and ß adrenergic receptors, sympathomimetic Cessation of Action: Metabolized by liver and other tissues via monoamine oxidase and catechol O-methyltransferase Cardiovascular Effects: - Activation of α-1 adrenergic receptors causes vasoconstriction - Activation of ß-1 receptors increases heart rate and contractility - Activation of ß-2 receptors causes relaxation of smooth muscle in the lungs leading to dilation and opening of airways - Marked increase in arrhythmogenicity Uses: Hypotension, Cardiac arrest, Heart failure, Airway edema, Bronchospasm, Anaphylaxis David Convissar, MD @countbackwardsfrom10 #Epinephrine #Adrenalin #Anesthesia #Pharmacology
