Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine, etc) - Viral: HIV, HCV, EBV, CMV - Bacterial: Sepsis - Parasitic: Malaria, babesia - Nutritional: B12, copper, folate def - Bone marrow infiltration: malignancy, infection (TB), MDS - Alcohol Consumption: - Microangiopathy: DIC, TTP, HUS - Antibody-mediated: ITP, HITT - Autoimmune: SLE, RA, antiphospholipid syndrome - Pregnancy: HELLP - Mechanical: valve replacement, endocarditis Splenic sequestration: - Cirrhosis with portal HTN - Anything causing splenomegaly SCVMC Internal Medicine @SCVMCMed #Thrombocytopenia #Differential #Diagnosis #Framework #hematology
