Lynch Syndrome:
• "CRC + Endometrial/Ovarian + Stomach + Urinary → Lynch Syndrome"
• Autosomal Dominant, 1 in 279 people
• Loss of expression in MLHI, MSH2, MSH6 or PMS2 or EPCAM genes
→ Mismatch Repair Defect → Microsatellite Instability (MSI)
• Previously thought to be but can have polyps; Proximal > Distal
by Dean Ehrlich MD @DeanEhrlich_MD
#Lynch #Syndrome #diagnosis #management #gastroenterology
