Irritable Bowel Syndrome (IBS) - Management Global IBS Symptoms: - Limited trial low FODMAP diet - Soluble, viscous, poorly fermentable fiber - Peppermint oil (Menthe piperita) - Tricyclic Antidepressants - Gut-directed psychotherapies IBS-D: - Rifaximin- up to 3 courses - Alosetron 0.5-1 mg BID in ♀ with severe symptoms who failed conventional tx - Mixed opioid agonists/antagonists (eluxadoline 75-100mg QD) IBS-C: - Secretagogues → activate receptors on apical membranes of intestinal epithelial cells intestinal secretion & peristalsis - 5-HT4 (Serotonin) agonist tegaserod 6mg BID in ♀ <65yo with 1 cardiovascular risk factors who failed secretagogues by Tina Hang, MD @TinaPhamHang via Emory Gastroenterology and Hepatology @EmoryGastroHep #IBS #Irritable #Bowel #Syndrome #Management #gastroenterology #treatment
