Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation causes an upregulation of Hepcidin which degrades ferroportin → Decreased ferroportin leads to decreased iron absorption and iron release
Diagnosis:
Ferritin <100 ng/mL (absolute ID) OR
Ferritin 100-299 ng/mL with TSAT <20% (functional ID)
Treatment - IV Iron:
• Several studies have shown significant improvement in symptoms and QOL and decreased hospitalizations
• Two meta analyses showed reduced risk for the composite endpoint of all-cause mortality and CV hospitalization
Alissa Shega, PharmD @alissa_shega
#iron #deficiency #CHF #HFrEF #heartfailure #diagnosis #management #cardiology
