How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is the Patient Receiving Anticoagulants (Vitamin K Antagonists, Heparin, or Direct Thrombin Inhibitor) Step 3: Is a Systemic Disease Prolonging the PT or APTT? Step 4: Mixing Studies to identify the cause of Prolonged APTT ISN Education @ISNeducation #Abnormal #APTT #prolonged #diagnosis #hematology #evaluation #mixing #studies #PTT