Post-Exposure Prophylaxis (PEP) for Pertussis • Highly contagious, secondary attack rate 80% in susceptible individuals! • Recommended for household & close contacts, regardless of vaccination status! • Exposure to symptomatic patient in the first 3 wks of illness - Face-to-face exposure within 3 feet - Direct contact w/ respiratory, nasal, or oral secretions Azithromycin - 500mg PO D1 → 250mg PO x4d OR TMP-SMX - 1 DS tab PO BID x14d #PostExposure #Prophylaxis #PEP #Pertussis #management