Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs as a result of capillary leak & tissue damage due to release of inflammatory cytokines induced by streptococcal toxins
Complicates invasive GAS in 30% of cases; 50% in nec fasc
Diagnostic Criteria:
• Isolation of GAS from sterile body site (i.e., blood)
• Early onset hypotension
• Multi-organ involvement (2+): kidneys, liver, lung/ARDS, coagulopathy, erythematous macular rash, soft tissue necrosis
STSS Treatment Strategy:
• Empiric therapy in suspected STSS: Clinda + vanco + pip-tazo or carbapanem
• Tailored therapy once dx established: Clinda + Penicillin G
- Linezolid if isolate clinda R
• Adjunctive: IVIG 1g/kg on day 1, 0.5g/kg on day 2 + 3
BIDMC Infectious Diseases Fellowship @BIDMC_IDFellows
#Streptococcal #Toxic #Shock #Syndrome #STSS #treatment #management #diagnosis
