Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide, Ampicillin, Methicillin, Carbenicillin • Ternary Complex (drug-antibody complex binds to RBC): Amphotericin B, Cefotaxime, Ceftriaxone, Cephalosporins, Chlorpropamide, Chlorpromazine, Diclofenac, Doxepin, Hydrochlorothiazide, Fenoprofen, Isoniazid, Melphalan, Nomifensine, Probenciden, Quinidine, Quinine, Probenecid, Rifampin, Tetracycline, Thiopental, Tolmetin • Autoantibody (induction of AIHA): Cephasporins, Tolmetin, Nomifensine, Methyldopa, Levodopa, Mefenamic acid, Teniposide, Procainamide, Diclofenac • Unknown: Chlorpromazine, Melphalan, Isoniazid, Acetaminophen, Thiazides, Ibuprofen, Erythromycin, Sulindac, Omeprazole, Sulfa drugs, Rifampin, Tricyclic antidepressants Dr. Thomas DeLoughery @Bloodman #Drugs #medications #Hemolytic #Anemia #differential #diagnosis #pharmacology #table
