Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP (Hemolysis, Elevated Liver tests, Low Platelets) * Variant of pre-eclampsia * High LDH, schistocytes, DIC * Responds to delivery of child * Severe cases may require plasma exchange 2) TTP * Occurs most often in 2nd trimester * Can support mother through pregnancy with plasma exchange 3) Fatty liver of pregnancy * Severe coagulation defects and liver failure * Responds to delivery of child Dr. Thomas DeLoughery @Bloodman #Pregnancy #Thrombocytopenia #TTPHUS #HELLP #AFLP #obstetrics #hematology #diagnosis #table #comparison
