Neuromodulators for Disorders of Gut Brain Interactions (DGBIs) SSRIs - When anxiety, depression, and phobic features are prominent with DGBls TCAs - First-line treatment when pain is dominant in DGBls Tetracyclic Antidepressant - Treatment of early satiety nausea/vomiting, weight loss and disturbed sleep SNRls - Treatment when pain in dominant in DGBls or when side effects from TCAs preclude treatment Augmentation: • Azapirones • Delta Ligand Agents • SSRI • Atypical Antipsychotics • Bupropion • Psychological Treatment CBT • DBT, EMDR • Hypnosis, Mindfulness, Relaxation #Neuromodulators #DGBIs #IBS #pharmacology #management
