Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS w/ eosinophilia • Familial/Genetic: Hyper-lgE (Job) syndrome, familial eosinophilia Secondary Eosinophilia: • Neoplastic: Solid tumors (esp. GI, lung, skin), Heme malig (AML, CML, T-cell leuk/lymphoma, B-cell lymphomas), Systemic mastocytosis, Langerhans cell histiocytosis • Allergic: Asthma, Eczema, Drug Hypersensitivity (DRESS, drug-induced eosinophilia, ABPA), Gleich syndrome (episodic angioedema w/ eosinophilia) • Infectious: Loeffler syndrome, Helminths (Strongy, Schisto, hookworm, filariasis, trichinella, ascariasis), Scabies, Fungi (Cocci, Aspergillus), Viral (HIV, HTLV-1), Mycobacteria (TB, Leprosy), Bacterial (syphilis, bartonella) • Rheum/AI: EGPA, IgG-4 disease, Behcet disease, Sarcoidosis, SLE, Eosinophilic esophagitis, Eosinophilic pneumonia, Adrenal insufficiency, Chronic inflammatory disease: e.g. IBD Stanford Internal Medicine Chiefs @StanfordChiefs #Eosinophilia #Differential #Diagnosis #Algorithm #allergy
