Two-step Copeptin algorithm for differential diagnosis of Diabetes Insipidus (DI) Baseline Copeptin < 21.4 pmol/L: • Arginine-stimulated Copeptin < 3.8 pmol/L → Complete or partial Central DI • Arginine-stimulated Copeptin ≥ 3.8 pmol/L → Primary polydipsia Baseline Copeptin ≥ 21.4 pmol/L (without prior thirsting) → Nephrogenic DI #Diabetes #Insipidus #DI #algorithm #copeptin #nephrology #differential #diagnosis
