Adie's Pupil What? Unknown nature & benign • Regular and mildly dilated pupil (4-6mm); • Light-near dissociaton; • Usually unilateral; • Slow pupillary dilation in response to dark; • Slow redilation when reexposed to light; • Normal response to mydriatics. Holmes-Adie Syndrome: • Adie's Pupil + Hyporeflexia • Young females Differential Diagnosis: • CN Ill Palsy - abnormal extraocular movements - no light-near dissociation • Other causes of tonic pupil (trauma/orbital tumor) • Physiologic Anisocoria - same pupillary asymmetry in dark and light By Dr. Gabriela Figueiredo Pucci @gabifpucci @neudrawlogy #Adies #Pupil #PhysicalExam #neurology #ophthalmology