Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and Anti-La (SSB), others (RNP, aPL antibodies)
• Antiphospholipid Antibody Syndrome: Anti-cardiolipin (aCl), ß2 glycoprotein I (ß2GP), Lupus Anticoagulant (LAC)
• Sjogren Syndrome: Anti-Ro (SSA), Anti-La (SSB)
• MCTD: Anti-UI RNP (ribonucleoprotein)
• RA: Rheumatoid Factor (RF), Cyclic Citrullinated Peptide (CCP)
• Myositis: Anti-JO-1, Others: SRP, Mi-2, TIF1y, MDA5
• Scleroderma (Systemic Sclerosis, SSc): Anti-centromere, Scl-70 (DNA topoisomerase I), RNA Polymerase Ill
• ANCA Vasculitis: P-ANCA (perinuclear), C-ANCA (cytoplasmic)
by Mithu Maheswaranathan, MD @MithuRheum via @RheumOnePagers
#Autoantibodies #Rheumatology #diagnosis #associations #table