Causes of Toxic Megacolon - Differential Diagnosis Framework • Inflammatory Bowel Disease: Ulcerative colitis, Crohn's colitis • Infection: Clostridium difficile, Amoebic dysentery, Disseminated cytomegalovirus, Shigella, Salmonella, Campylobacter, Aspergillus, Cryptosporidiosis, Yersinia, Hemolytic-uremic syndrome (complicating Escherichia coli 0157 infection) • Other Disorders: Ischemic colitis, Diverticulitis, Obstructing colonic carcinoma, Colonic volvulus • Factors associated with triggering Opioids (including loperamide) or worsening of toxic dilatation: 5-HT3 antagonists, Anticholinergics, Hypokalaemia, Hypomagnesaemia, Overdistension at colonoscopy, Overdistension during radiology, Chemotherapy #Toxic #Megacolon #Differential #Diagnosis #Causes
