Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly to mast cells- contain histamine in their granules which are released during an allergic reaction or asthma attack Is It A Real Basophilia? • Pseudobasophilia possible. • Statistical error/delay in processing Myeloproliferative Disorders: • Chronic myeloid leukemia (CML) - associated with the BCR-ABL1 fusion gene - reciprocal t(9;22) translocation • Acute myeloid leukemia - Basophils + circulating blasts • Polycythemia Vera • Essential thrombocythemia • Acute basophilic leukemia Hypersensitivity Or Inflammatory Reactions: • Ulcerative Colitis and Crohn’s Disease • Asthma Hypothyroidism (Myxedema) Diabetes/DKA Infections: • helminth infections • Tuberculosis • Influenza • Chickenpox Other Causes: • Iron deficiency • Irradiation • Cirrhosis • Estrogen therapy #Basophilia #Differential #Diagnosis #causes #hematology #basophils
