Causes of Angioedema: Differential Diagnosis Framework Mast-cell mediated: • IgE dependent allergic reactions: Food, Drugs, Latex, Stings • Direct mast cell release: Opiates, Radiocontrast • Changes in arachidonic acid metabolism within mast cells: NSAlDs, Aspirin Bradykinin mediated: • ACEi • Hereditary C1 esterase inhibitor deficiency (hereditary angioedema) • Acquired C1 esterase inhibitor deficiency • Fibrinolytics Unknown Mechanisms: • Idiopathic • Infections • CCV #Angioedema #Differential #Diagnosis #Causes #allergy
