Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver failure 1) Hepatocellular (disproportionate increase in AST/ALT compared with alkaline phosphatase) 2) Cholestatic (disproportionate increase in alkaline phosphate compared with AST/ALT) Hepatocellular Liver Injury Differential Diagnosis: • Infections: Hepatitis A/B/C/D/E, EBV, CMV, HSV, VZV • Medications (APAP, PTU, isoniazid, phenytoin, valproate, azoles), Drugs (MDMA), Alcohol, Iron, Mushrooms (Amanita phalloides) • Vascular: Ischemic, Congestion, Budd Chiari • Hereditary: Hemochromatosis, Wilson's disease, Alpha-1 antitrypsin • Other: NAFLD, Autoimmune, HELLP, Celiac disease, Malignancy by Lauren Banaszak, MD @LaurenBzak via @uw_IMresidency #Hepatocellular #Liver #Injury #Differential #Diagnosis #hepatology #algorithm #Transaminitis #LFTs #hepatitis
