Extra-articular and Other Conditions Associated with Joint Pain
Eyes
• Iritis or uveitis - Spondyloarthropathies, Sarcoidosis, GPA
• Conjunctivitis - Spondyloarthropathies, SLE, GPA
• Cytoid bodies (retinal exudates) - SLE
• Scleritis - RA, Relapsing polychondritis, GPA
• Ischemic optic neuritis - Giant cell arteritis, GPA
• Iridocyclitis - Juvenile idiopathic arthritis
Nails
• Onycholysis - Psoriatic arthritis, Hyperthyroidism
• Pitting - Psoriatic arthritis
• Clubbing - IBD, Whipple's disease, Hyperthyroidism
Fever
• Bacterial or viral infection
• Still's disease
• Subacute bacterial endocarditis
• Neoplasm
Nodules
• RA
• Gout
• Whipple's disease
• Rheumatic fever
• Amyloidosis
• Sarcoidosis
• Tophi
- Gout
• Jaundice
- Hepatitis
- Hemochromatosis
• Hyperpigmentation
- Whipple's disease
- Hemochromatosis
GI
- Felty syndrome
- Spondyloarthropathy-IBD
- Splenomegaly
• Felty's syndrome
• Tumor-associated arthritis
- Hepatomegaly
• Whipple's disease
• Hemochromatosis
• Amyloidosis
• Wilson's disease
Pulmonary
• Interstitial lung disease - Spondyloarthropathies, SLE
• Pulmonary nodules - RA, SLE
• Pleural disease - RA - SLE
• Bronchiectasis - RA
• Shrinking lung syndrome - SLE
Neurologic system
• Entrapment neuropathies - RA, Hypothyroidism, Hyperparathyroidism
• Facial palsy - Lyme disease
• Peripheral neuropathy - SLE, Amyloidosis
• Chorea - Antiphospholipid-antibody syndrome, SLE, Rheumatic fever
• Mononeuritis multiplex - RA, SLE, Lyme disease, Vasculitis (e.g., PAN)
• Seizures - SLE
Genitourinary system
• Prostatitis - Reactive arthritis, Ankylosing spondylitis
• Urethritis or cervicitis - Reactive arthritis, Gonococcal arthritis
• Scrotal or vulvar ulcers - Behçet's syndrome
• Hypogonadism - Hemochromatosis
• Balanitis circinata - Reactive arthritis
ENT
• Oral ulcers - SLE, Behçet's syndrome, Reactive arthritis, GPA
• Parotid enlargement - Sjögren's syndrome, Sarcoidosis
• Macroglossia - Amyloidosis
• Scalp tenderness - Giant cell arteritis
• Bloody or severe sinusitis - GPA
• Inflammation of ear, sparing the lobe - Relapsing polychondritis
Telangiectasia
• Scleroderma
Thickened skin
• Scleroderma
• Amyloidosis
• Eosinophilic fasciitis
Hair thinning
• Hypothyroidism
• SLE
Musculoskeletal System Tender points
• Fibromyalgia
Heberden's nodes (DIP joints), Bouchard's nodes (PIP joints)
• Osteoarthritis
Boutonnière and swan-neck deformities
• RA, SLE, Ehlers-Danlos syndrome
Dactylitis of digits
• Psoriatic arthritis
Lymphadenopathy
• Tumor-associated arthritis
• SLE
Cardiovascular system
• Mitral regurgitation and stenosis - Rheumatic fever
• Aortic regurgitation - Ankylosing spondylitis, Rheumatic fever, Relapsing polychondritis, Reactive arthritis, Marfan syndrome, Takayasu's arteritis
• Cardiomyopathies - Viral infection, Amyloidosis, Sarcoidosis, SLE, Polymyositis
• New murmur, fever - Bacterial endocarditis, Rheumatic fever
• Diminished peripheral pulses - Giant cell arteritis, Takayasu's arteritis
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