Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids, Phosphate Binders, Vitamin D Deficiency • Transcellular Shift: Refeeding Syndrome, Acute Respiratory Alkalosis, Tumor Genesis Syndrome Inappropriately High Kidney Phosphate Excretion: • N Vitamin D: Primary Hyperparathyroidism, TKI, ALK inhibitor, Estrogen based hormonal therapy, IV Bisphosphonate and Denosumab • ↓Vitamin D: Vit D Deficiency • N or ↓FGF23: Fanconi Syndrome, (MM, lymphoma, cancer therapy) • ↑FGF23: Oncogenic, Osteomalacia, Ferric Carboxymaltose, CAR-T cell #Hypophosphatemia #Differential #Diagnosis #Algorithm #nephrology #phosphorus #workup
