Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis • Cervicofacial actinomycosis • Mumps • Lymphadenitis • Sinusitis • Tonsillitis • Peritonsillar abscess • Dentitio difficilie • OM of craniofacial bones • Pott's puffy tumor Autoimmune: • SLE • Dermatomyositis/polymyositis • Adult-onset Still's disease • Sjogren's syndrome Hypersensitivity: • Angioedema • DRESS/DIHS • Nonepidosic angioedema with eosinophilia (NEAE) • Contact dermatitis (CD) Orbital/Periorbital Space: • Cavernous venous thrombosis • Orbital cellulitis • Rhinocerebral mucormycosis • Aspergillosis sinusitis • Trichinosis Salivary Gland: • Sialoadenitis • Parotitis Preeclampsia Dermatologic: • Sunburn • DRESS/DIHS • Rosacea • Solid facial edema of acne Medications: • ACE inhibitors/ARBs • Corticosteroids • Estrogen • Non-steroidal anti-inflammatory drugs • Thiazolidinediones • Calcium channel blockers Trauma: • Ocular trauma/hematoma • LeFort fractures of the midface • Facial fractures in patients with multi-organ trauma • Zygomatic arch fractures associated with trismus • Nasoethmoid fractures • Subcutaneous emphysema Renal: • Nephrotic syndrome • Central venous stenosis/obstruction in hemodialysis patients with central line catheters Endocrine: • Cushing's syndrome • Decompensated hypothyroidism/Myxedema coma Vascular: • SVC syndrome • Bilateral internal jugular vein thrombosis • Central venous stenosis/obstruction in hemodialysis patients with central line catheters Malignancy: • SVC syndrome • Sebaceous gland carcinoma • Multiple myeloma - maxillofacial region • Idiopathic angiosarcoma of the head and neck • Cutaneous lymphomas • Head and neck squamous cell carcinoma • Parapharyngeal space tumors • Richter's syndrome - CLL Others: • Morbihan disease • Melkersson-Rosenthal syndrome • Pseudolymphoma • Heerfordt syndrome - Sarcoidosis • Post-operative • Post-radiotherapy states • Acute mountain sickness #Facial #Swelling #Edema #Differential #Diagnosis #PhysicalExam
