Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy (Bronchogenic carcinoma, Bronchial carcinoid, Mets), COPD, Cystic fibrosis, Bronchovascular fistula, Foreign body Parenchyma: • Infection: Bacterial (TB, Necrotizing PNA, Abscess), Viral (Influenza, Ebola, Dengue), Fungal (Aspergillosis, Mycetoma, Mucor), Parasitic (Paragonimus, Strongy) • Malignancy: Primary lung, Mets, Kaposi's sarcoma • Rheumatologic / Autoimmune: ANCA-Assoc vasculitis (GPA > EGPA, MPA), Cryoglobulinemia, Goodpasture's, SLE Cardiac: • Valvular (Mitral stenosis or regurgitation, Tricuspid endocarditis), Heart failure Vascular: • Diffuse alveolar hemorrhage (DAH), AVM, Thoracic aortic aneurysm Misc / Other: • Idiopathic • Coagulopathy: DIC, vWD • Endometriosis: Catamenial, hemoptysis • Trauma: Postprocedural, Lung contusion • Drugs / Toxins: Cocaine, Vaping, Bevacizumab Mimics: • GI bleed: esophageal varices, PUD, gastritis • Nasopharyngeal bleeding By Dr. Kristen Carroll via @NUIM_Chiefs #Hemoptysis #Differential #Diagnosis #pulmonary #causes
