Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal - Acute Viral Hepatitis, Toxic Hepatitis 10-20x normal - Infection (EBV/CMV), Alcoholic cirrhosis, Portal Vein Thrombosis 5-10x normal - Chronic hepatitis, Skeletal muscle 2-5x normal - Hemolysis, NASH, Genetic / Metabolic. By AST:ALT Ratio: AST:ALT = 1 - Ischemia, CHF AST:ALT > 2.5 - Alcoholic Hepatitis AST:ALT < 1 - Viral Hepatitis, Ischemic Necrosis, Toxins By Dr. Khushboo Gala @LouLectures #Patterns #Liver #Injury #hepatology #LFTs #transaminitis #differential #diagnosis
