Acute Kidney Injury (AKI) - Differential Diagnosis Framework Prerenal: • Due to true volume loss or decreased effective arterial blood volume • Hypovolemia: Dehydration, GI losses, hemorrhage, diuretics, burns, 3rd spacing • Decreased effective arterial supply: cardiorenal, hepatorenal, sepsis • Drugs: NSAIDs, ACEI/ARB Intrinsic: • Due to damage to the glomeruli, tubules, or interstitium • ATN (Acute tubular necrosis) • Ischemic • Toxic (some abx, heme pigment, contrast dye) • AIN (acute interstitial nephritis) • GN (glomerulonephritis) Postrenal: • Due to damage/obstruction along the urinary tract system • Cellular debris • Kidney stone • Tumor • Prostate enlargement • Trauma to the urinary tract By Dr. Liza Cholin @LouLectures #Acute #Kidney #Injury #AKI #Differential #Diagnosis #nephrology
