Capnocytophaga Pathogen: Capnocytophaga • 9 species, C. canimorsus responsible for the majority of infections • Gram-negative rod, Facultative anaerobe, SIow growing, Long, thin, and fusiform • Capnophilic "carbon loving' Risk Factors: • Part of the oral flora of healthy cats and dogs. Transmitted to humans through animal bites. • Asplenia (greatest risk), Malignancy, SLE, Corticosteroids, alcohol use, Cirrhosis Presentation: • Incubation period is 1-5 days, Mortality 30-50% • Cellulitis: Fever, Chills, General malaise • Septic shock: Hypotension, Purpura Fulminans, Gangrene • Multiorgan failure: CID, Renal failure, Encephalopathy • Other Presentations: FUO, Meningitis (13%), Pneumonia, Endocarditis, Septic arthritis, Cholecystitis Diagnosis: • Fastidious microorganism (Culture I - 14 days incubation period) • Buffy coat stain: Peripheral smear for fusiform gram-negative within the cytoplasm of PMN. • Sensitivity and specificity of PCR is not well defined. Treatment: • 50% resistant to fluoroquinolones • Zosyn, Imipenem-Cilastatin, Meropenem, Clindamycin Prophylaxis (Dog bite in asplenic patient): Augment, Clindamycin By @TheIDtrivia #Capnocytophaga #canimorsus #microbiology #zoonotic #infectiousdiseases #diagnosis #management #treatment
