Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
• Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia, Parathyroid carcinoma, Lithium
• Familial Hypocalciuric Hypercalcemia
Low PTH:
• High PTHrP: Malignancy
• Normal PTHrP:
- Low 25 VitD: Multiple Myeloma, Skeletal metastatic disease, Milk Alkali Syndrome, Immobilization, Drugs, Endocrine disorders, Paget's disease, Viral Syndromes
- High 25 VitD: Vit D Intoxication
- High 1, 25 VitD: Lymphoma, Granulomatous diseases, Idiopathic calcitriol induced hypercalcemia, Infantile idiopathic hypercalcemia
Dr. Aisha Shaikh @aishaikh
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