Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers) • Angiotensin-converting enzyme (ACE) inhibitors (Lisinopril) • Angiotensin II Receptor Blockers (Losartan) • Synthesis of aldosterone inhibition (Heparin) • Sodium-channel blockers (Amiloride, Triamterene, Trimethoprim) • Aldosterone Antagonist (Spironolactone) • Calcineurin Inhibitors (Tacrolimus, Cyclosporine) • Increased EC shift of K (Succinylcholine) • Exogenous (KCL, Benyzlpenicillin, blood) Dr. Muner Mohamed @MunerMohamed1 #hyperkalemia #differential #diagnosis #pathophysiology #pharmacology #potassium #medications #druginduced
