Cardiomyopathies Manifestations of cardiomyopathy (CM) range from microscopic alterations in cardiac myocytes to fulminant Heart Failure with inadequate perfusion, fluid accumulation, & cardiac rhythm dysfunction. Divided into 2 major groups based on predominant organ involvement. Primary Cardiomyopathies: • Hypertrophic Cardiomyopathy • Arrhythmogenic Right Ventricular Cardiomyopathy • LV Noncompaction • Channelopathies • Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) • Short QT Syndrome • Dilated Cardiomyopathy (DCM) • Restrictive Cardiomyopathy • Myocarditis • Stress (Takotsubo) Cardiomyopathy • Peripartum/Postpartum Secondqry cardiomyopathies - Pathological myocardial involvement as part of a large number & variety of generalized systemic (multiorgan) disorders: • Infiltrative (Amyloidosis, Gaucher, Hurler's & Hunter's). • Storage (Hemochromatosis, Fabry's disease, Glycogen storage) • Toxicity (Drugs. heavy metals. chemical agents) • Endomyocardial (Fibrosis. Hypereosinophilic syndrome) • Inflammatory (granulomatous) - Sarcoidosis • Endocrine (DM, Hyper/hypothyroidism, ↑PTH, Pheochromocytoma. Acromegaly) • Neuromuscular/neurological (Friedreich's ataxia. Duchenne-Becker dystrophy, Neurofibromatosis, TS) • Nutritional deficiencies (Beriberi. pellagra. scurvy. selenium) • Autoimmune/collagen (SLE, RA. Dermatomyositis, Scleroderma, Polyarteritis nodosa) • Electrolyte imbalance • Cancer Therapy (Anthracyclines. Cyclophosphamide. Radiation) Satyendra Dhar, MD @DharSaty #Cardiomyopathies #cardiology #diagnosis #differential #cardiomyopathy
