Satyendra Dhar, MD @DharSaty · 2 years ago
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D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
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D-dimer
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated plasma D-dimer levels indicate that coagulation has been activated, fibrin clot has formed, & clot degradation by plasmin has occurred.

D-dimer has been shown to increase with age, which can cause a ↓ specificity (i.e. more false positive tests) in older patients. Specificity can range from 49-67% in 50 yrs of age, but in older patients (i.e. 80 yrs of age) the specificity is 0-18%

How do you perform age adjusted d-dimer testing?
 - Age (yrs) x 10 u g/ L for > 50 yrs of age
 - Example: Patient age 88 = age adjusted d-dimer of 880 u g/ L

Satyendra Dhar, MD @DharSaty

#Ddimer #dimer #pathophysiology #hematology #differential #diagnosis #age #adjusted
Satyendra Dhar, MD @DharSaty · 2 years ago
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