Satyendra Dhar, MD @DharSaty · 3 years ago
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D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
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D-dimer
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated plasma D-dimer levels indicate that coagulation has been activated, fibrin clot has formed, & clot degradation by plasmin has occurred.

D-dimer has been shown to increase with age, which can cause a ↓ specificity (i.e. more false positive tests) in older patients. Specificity can range from 49-67% in 50 yrs of age, but in older patients (i.e. 80 yrs of age) the specificity is 0-18%

How do you perform age adjusted d-dimer testing?
 - Age (yrs) x 10 u g/ L for > 50 yrs of age
 - Example: Patient age 88 = age adjusted d-dimer of 880 u g/ L

Satyendra Dhar, MD @DharSaty

#Ddimer #dimer #pathophysiology #hematology #differential #diagnosis #age #adjusted
Satyendra Dhar, MD @DharSaty · 3 years ago
Hospital Medicine Clinical Assistant Professor The content and images on this website are provided for educational and informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. The views expressed are those of the authors and do not necessarily reflect those of any affiliated institutions. While efforts are made to ensure accuracy and currency, medical knowledge is continually evolving, and errors or omissions may occur. Users are advised to independently verify information and seek guidance from qualified healthcare professionals for any medical decisions. By using this website, you acknowledge responsibility for your own clinical judgments, and the website and its contributors disclaim any liability arising from the use of its content. 👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
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