Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed against the glomerular basement membrane and alveolar basement membrane, resulting in rapidly progressive glomerulonephritis and/or alveolar hemorrhage Diagnosis: • Anti-GBM antibodies in one of the following: Serum, Kidney biopsy • OR pathognomonic pattern on kidney biopsy Treatment: • Pulse dose steroids (typically 1000mg QD for 3 days) • Immunosuppression: Cyclophosphamide is 1st-line, Rituximab is 2nd-line • +/- Plasmapheresis: Daily sessions to clear active antibodies for 2-3 weeks By Tess Litchman, MD @TessLitchman via @PulmPEEPs #Anti #GIomeruIar #Basement #Membrane #Disease #Goodpastures #AntiGBM #diagnosis #nephrology #pulmonary
