Clopidogrel (Plavix) and Clopidogrel Non-responders Clopidogrel is an irreversible selective inhibitor of the platelet low-sensitivity adenosine diphosphate receptor: P2Y12 Clopidogrel non-responders: • Most commonly implicated is a genetic polymorphism in CYP2C19 activity making the individual a poor or intermediate metabolizer of clopidogrel to its active metabolite • Another factor to consider is co-administration of strong CYP2C19 inhibitors - These include PPIs (most notably omeprazole), antifungals (most notably fluconazole), and fluoxetine By Dr. Kathryn Watson @Kat_Watson #Clopidogrel #Plavix #Nonresponders #pharmacology #toxicology
