CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic Meningitis, Myelopathy, Encephalopathy, Cognitive Dysfunction, Cerebrovascular Disease, PRES Pathophysiology: Pathogenesis involves the formation of autoantibodies that will cause ischemia and/or inflammation, leading to vasculopathy, thrombosis and/or blood-brain barrier permeability Diagnosis of Lupus Cerebritis: Labs, Imaging, Lumbar Puncture, EEG Treatment: • Inflammatory Pathway - Lupus Cerebritis Induction Rx: high-dose glucocorticoids + cyclophosphamide • Ischemic Pathway - Aspirin, anticoagulants (for secondary APS), Secondary prevention (statin for CVA) By Dr. Gabriela Figueiredo Pucci @gabifpucci (@neudrawlogy) and Mithu Maheswaranathan, MD @MithuRheum (@RheumOnePagers) #Systemic #Lupus #Erythematosus #SLE #CNS #neurology #rheumatology #cerebritis #diagnosis #management #treatment
