Statins & Recommendations:
Word Cholesterol came from Cholesterine, named by French chemist Michel E. Chevreul (‘solid bile’ in Greek: ‘chole’ for bile and ‘stereos’ for solid). Exact formula of cholesterol was established in 1888 by Friedrich Reinitzer. Merck Labs found first statin, 1978, in a fermentation broth of Aspergillus terreus, named mevinolin & later lovastatin.
Statins inhibit the critical step of cholesterol synthesis in which 3-hydroxy-3-methylglutaryl coenzyme A (HMGC) is transformed to mevalonate by the enzyme HMGC reductase. By doing so, they have a potent lipid-lowering effect that reduces cardiovascular risk and decreases mortality. Since the mevalonate pathway also influences endothelial function, the inflammatory response, and coagulation, the effects of statins reach well beyond their cholesterol lowering properties. As with all drugs, statins may have adverse effects; these include musculoskeletal symptoms, increased risk of diabetes, and higher rates of hemorrhagic stroke. However, the frequency of adverse effects is extremely low and, in selected patient populations, the benefits of statins considerably outweigh the potential risks.
Satyendra Dhar MD, @DharSaty
#Statins, #Myositis, #Diabetes, #Stroke#CAD
Hospital Medicine
Assistant Clinical Professor
The images and content on this website are furnished solely for didactic and elucidative purposes. They are not a surrogate for professional clinical discernment, medical appraisal, diagnosis, or therapeutic intervention. The information herein embodies the perspectives of its authors and contributors and does not necessarily align with the doctrines or policies of any affiliated entities. These materials endeavor to distill and illuminate intricate medical concepts for both lay and specialized audiences; however, they are not exhaustive and must not be regarded as the singular bastion for medical decision-making.
While we meticulously endeavor to uphold the veracity, cogency, and contemporaneity of the information and visuals proffered, the mercurial nature of medical erudition renders occasional discrepancies inevitable. Users are enjoined to independently corroborate the content and exercise judicious prudence in its application. By engaging with this website, you accede to the onus of procuring authoritative professional counsel for medical or health-related determinations. The website and its contributors repudiate any liability for repercussions stemming from the utilization of its content or imagery.
👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
Statins & Recommendations:
Word Cholesterol came from Cholesterine, named by French chemist Michel E. Chevreul (‘solid bile’ in Greek: ‘chole’ for bile and ‘stereos’ for solid). Exact formula of cholesterol was established in 1888 by Friedrich Reinitzer. Merck Labs found first statin, 1978, in a fermentation broth of Aspergillus terreus, named mevinolin & later lovastatin.
Statins inhibit the critical step of cholesterol synthesis in which 3-hydroxy-3-methylglutaryl coenzyme A (HMGC) is transformed to mevalonate by the enzyme HMGC reductase. By doing so, they have a potent lipid-lowering effect that reduces cardiovascular risk and decreases mortality. Since the mevalonate pathway also influences endothelial function, the inflammatory response, and coagulation, the effects of statins reach well beyond their cholesterol lowering properties. As with all drugs, statins may have adverse effects; these include musculoskeletal symptoms, increased risk of diabetes, and higher rates of hemorrhagic stroke. However, the frequency of adverse effects is extremely low and, in selected patient populations, the benefits of statins considerably outweigh the potential risks.
Satyendra Dhar MD, @DharSaty
#Statins, #Myositis, #Diabetes, #Stroke#CAD
Hospital Medicine
Assistant Clinical Professor
The images and content on this website are furnished solely for didactic and elucidative purposes. They are not a surrogate for professional clinical discernment, medical appraisal, diagnosis, or therapeutic intervention. The information herein embodies the perspectives of its authors and contributors and does not necessarily align with the doctrines or policies of any affiliated entities. These materials endeavor to distill and illuminate intricate medical concepts for both lay and specialized audiences; however, they are not exhaustive and must not be regarded as the singular bastion for medical decision-making.
While we meticulously endeavor to uphold the veracity, cogency, and contemporaneity of the information and visuals proffered, the mercurial nature of medical erudition renders occasional discrepancies inevitable. Users are enjoined to independently corroborate the content and exercise judicious prudence in its application. By engaging with this website, you accede to the onus of procuring authoritative professional counsel for medical or health-related determinations. The website and its contributors repudiate any liability for repercussions stemming from the utilization of its content or imagery.
👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
Statins & Recommendations:
Word Cholesterol came from Cholesterine, named by French chemist Michel E. Chevreul (‘solid bile’ in Greek: ‘chole’ for bile and ‘stereos’ for solid). Exact formula of cholesterol was established in 1888 by Friedrich Reinitzer. Merck Labs found first statin, 1978, in a fermentation broth of Aspergillus terreus, named mevinolin & later lovastatin.
Statins inhibit the critical step of cholesterol synthesis in which 3-hydroxy-3-methylglutaryl coenzyme A (HMGC) is transformed to mevalonate by the enzyme HMGC reductase. By doing so, they have a potent lipid-lowering effect that reduces cardiovascular risk and decreases mortality. Since the mevalonate pathway also influences endothelial function, the inflammatory response, and coagulation, the effects of statins reach well beyond their cholesterol lowering properties. As with all drugs, statins may have adverse effects; these include musculoskeletal symptoms, increased risk of diabetes, and higher rates of hemorrhagic stroke. However, the frequency of adverse effects is extremely low and, in selected patient populations, the benefits of statins considerably outweigh the potential risks.
Satyendra Dhar MD, @DharSaty
#Statins, #Myositis, #Diabetes, #Stroke#CAD
Hospital Medicine
Assistant Clinical Professor
The images and content on this website are furnished solely for didactic and elucidative purposes. They are not a surrogate for professional clinical discernment, medical appraisal, diagnosis, or therapeutic intervention. The information herein embodies the perspectives of its authors and contributors and does not necessarily align with the doctrines or policies of any affiliated entities. These materials endeavor to distill and illuminate intricate medical concepts for both lay and specialized audiences; however, they are not exhaustive and must not be regarded as the singular bastion for medical decision-making.
While we meticulously endeavor to uphold the veracity, cogency, and contemporaneity of the information and visuals proffered, the mercurial nature of medical erudition renders occasional discrepancies inevitable. Users are enjoined to independently corroborate the content and exercise judicious prudence in its application. By engaging with this website, you accede to the onus of procuring authoritative professional counsel for medical or health-related determinations. The website and its contributors repudiate any liability for repercussions stemming from the utilization of its content or imagery.
👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
