Whipple Disease (Tropheryma whipplei) - Diagnosis and Management Caused by: Tropheryma whipplei Symptoms and Signs: 1. Migratory poly/oligoarthralgia (80%) 2. Weight loss (90%) 3. Abdominal pain; colicky (60%) 4. Intermittent diarrhea (75%) Diagnostic Criteria - Either one of: • Oculomasticatory/oculo-facial-skeletal myorhythmia OR • PAS-positive macrophages from a small bowel biopsy OR • Two different positive T. whipplei tests (PAS, PCR, or IHC) from the same specimen OR • One positive T. whipplei test (PAS, PCR, or IHC) from two different specimens Matthew Ho, MD PhD @MatthewHoMD #Whipple #Disease #diagnosis #algorithm #management #criteria #Tropheryma #whipplei
