Iron Deficiency Anemia - Differential Diagnosis Algorithm
Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR
• Blood loss: GI bleed, GU bleed, Gyn bleed, Epistaxis, Surgery, Hemodialysis
• Iron loss: Intravascular (not extravascular) hemolysis, Intensive athletic training, Pulmonary hemosiderosis
• Malabsorption:
- Achlorhydria: PPI/H2 blocker, H. pylori, Atrophic gastritis, Gastrectomy, WHDA syndrome, Vagotomy
- Structural: Celiac disease, Tropical sprue, IBD, Bypass surgery, Bacterial overgrowth, Hookworm, whipworm
- Other nutrients: Zinc excess or deficiency, Copper deficiency, Lead poisoning
• Inadequate intake: Anorexia, Pregnancy, Lactation, Low iron diet, Alcoholism, Tea-toast, TPN
Matthew Ho, MD PhD @MatthewHoMD
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