Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% • Females: Hb > 16 g/dL/HCT ≥ 48% Polycythemia Vera Secondary Polycythemia - Acquired Causes: • Hypoxia-driven: Cardiac/pulmonary disease, Smoking/CO poisoning, OSA/OHS, High altitude habitat • Hypoxia-independent: Post-renal transplant, Paraneoplastic (e.g., RCC, HCC, uterine fibroids, cerebellar hemangioblastoma, pheochromocytoma), TEMPI (VEGF normal), Testosterone/drug use Matthew Ho, MD PhD @MatthewHoMD #Erythrocytosis #Polycythemia #Vera #PV #Differential #Diagnosis #Algorithm #hematology
