Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH • ↑ Indirect / unconjugated bilirubin • ↑ Reticulocytes • Abnormal peripheral smear Immune-mediated Hemolysis: • Autoimmune Hemolytic Anemias (AIHAs) • Alloimmune Hemolytic Anemias (AHAs) Nonimmune-mediated Hemolysis: • Extrinsic RBC Defects: Hypersplenism, Infection, Toxic, Mechanical, Macroangiopathic, Microangiopathic • Intrinsic RBC Defects: Membrane defects, Enzyme deficiencies, Hemoglobinopathies Matthew Ho, MD PhD @MatthewHoMD #Hemolytic #Anemias #Differential #Diagnosis #Algorithm #hematology
